Expanded Repeat Sequences Raise a Person’s Risk for Alzheimer’s
Two studies tie repeated stretches of DNA to increased odds for AD. One encodes poly-GR peptides that aggregate.
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Proteomics Lays Groundwork for FTD Biomarkers
Surveys of CSF proteins from the GENFI and ALLFTD genetic cohorts flag altered biological processes and point toward FTD fluid markers.
Expunging Microglial Lipid Droplets Boosts Phagocytosis
An endoplasmic reticulum protein helps lipids bud from this organelle. Knocking out the protein in microglia curtailed lipid droplets, and enhanced amyloid clearance.
Single-Molecule Imaging Spies Protein Aggregates in Synapses
A new super-resolution microscopy technique sheds light on synaptic dysfunction.
From the Meninges, Regulatory T Cells Keep Brain Inflammation in Check
Mice have a small pool of such Tregs. Removing them hobbles the hippocampus, beckons immune invasion, revs glia, and quashes neurogenesis.
ApoE3 Christchurch Clings Tightly to Tau, Averting Tangles
In AD mouse models, replacing ApoE3 with ApoE3Ch preserves memory.
Leqembi Maintenance Dosing Approved in the U.S.
The nod will allow people who have completed 18 months of biweekly IV dosing to transition to monthly IVs. An application for subcutaneous dosing is pending.
C-Terminal Amidation Sends Proteins to the Shredder
Triggered by oxidative stress, this degradation signal may protect neurons.
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